LEON's FR-JET® Mixer Enhances mRNA-LNP Manufacturing

A recent study published in Pharmaceutics reveals that LEON's FR-JET® modular mixer effectively addresses manufacturing challenges in producing high-concentration lipid nanoparticles (LNPs). This innovation allows LNP formulation at concentrations higher than current industry standards, improving biological function and storage stability.

Dr. Blerina Shkodra, the lead author, emphasizes that this technology improves manufacturing efficiency and enhances in vivo potency, enabling faster and more efficient delivery of mRNA therapies. Compared to traditional methods that face issues like clogging and scalability, the FR-JET® mixer offers reliable scaling and process intensification.

Key benefits of employing higher lipid mixture concentrations include improved manufacturability, enhanced product performance, and better stability and scalability from development to manufacturing. LEON's CEO, Dr. Wolfgang Hofmann, highlights the study as a validation of the FR-JET® technology, marking a new era for LNP manufacturing.